A coffee enema is a type of colon cleanse used in alternative medicine. During the procedure, a mixture of brewed, caffeinated coffee and water is inserted into the colon through the rectum. An alternative treatment used to “cleanse the colon,” a coffee enema involves introducing a mixture of coffee and water into the colon by way of the rectum. Proponents suggest that coffee enemas can aid in detox and clear potentially harmful substances from the body.